Myoglobin

An early biomarker to aid in the diagnosis of myocardial infarction

Myoglobin
 
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Following myocadial necrosis associated with myocardial infarction (MI), myoglobin is one of the first markers to rise above normal levels, increasing measurably above baseline within 2-4 hours post-infarct, peaking at 9-12 hours, and returning to baseline within 24-36 hours.1,2 In the absence of skeletal muscle trauma or other factors associated with a non-cardiac related increase in circulating myoglobin, myoglobin levels have been used as an early marker for MI.3,4 A number of reports suggest the measurement of myoglobin as a diagnostic aid in “ruling-out” myocardial infarction with negative predictive values of up to 100% reported at certain time periods after onset of symptoms.

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1 Mair J, et al. Rapid diagnosis of myocardial infarction by immunoturbidimetric myoglobin measurement (letter). Lancet, 1991;337:1343.
2 Chapelle, JP. Myoglobin. Clin Chem. News, 1991;17:22.
3 Silva DP, et al. Development and application of antibodies to human cardiac myoglobin in rapid fluorescence Immunoassay. Clin. Chem., 1991;37:1356.
4 Hamfelt A, et al. Use of biochemical tests for myocardial infarction in the county of Vasternorrland, a clinical chemistry Routine for the diagnosis of myocardial infarction. Scand. J. Clin. Lab. Invest. Suppl.,1990;200:20.